Cann P A, Read N W, Holdsworth C D
Gut. 1984 Feb;25(2):168-73. doi: 10.1136/gut.25.2.168.
The effect of open treatment with coarse wheat bran was compared with response to placebo, given in the form of a double blind, cross over drug trial, in patients with irritable bowel syndrome. Both bran and placebo significantly reduced the severity of most of the symptoms. Constipation was the only symptom that improved significantly with bran, but not with placebo, and was the only symptom that predicted a successful outcome with bran. Diarrhoea did not improve with bran. In fact, stools became less formed in patients presenting with this symptom. The incidence of pain and urgency was significantly more frequent on bran compared with placebo. Compared with a baseline period, bran treatment resulted in an acceleration of whole gut transit time (p less than 0.05) increases in daily stool weight (p less than 0.01) and the proportion of unformed stools (p less than 0.01) but no change in stool frequency. Coarse wheat bran was no better than placebo for most symptoms in irritable bowel syndrome, although its efficacy in constipation was confirmed.
在肠易激综合征患者中，采用双盲交叉药物试验的形式，比较了粗麦麸开放治疗与安慰剂治疗的效果。麸皮和安慰剂均能显著减轻大多数症状的严重程度。便秘是唯一使用麸皮后症状显著改善而使用安慰剂后未改善的症状，也是唯一预示麸皮治疗能取得成功结果的症状。腹泻使用麸皮后并未改善。事实上，出现这种症状的患者大便变得更不成形。与安慰剂相比，服用麸皮时疼痛和便急的发生率明显更高。与基线期相比，麸皮治疗导致全肠道转运时间加快（p<0.05），每日大便重量增加（p<0.01）以及不成形大便的比例增加（p<0.01），但大便频率没有变化。对于肠易激综合征的大多数症状，粗麦麸并不比安慰剂更好，尽管其在便秘方面的疗效得到了证实。
