Wiedermann C J, Sacerdote P, Propst A, Propst T, Judmaier G, Kathrein H, Vogel W, Panerai A E
Department of Internal Medicine, School of Medicine, University of Innsbruck, Austria.
Brain Behav Immun. 1994 Sep;8(3):261-9. doi: 10.1006/brbi.1994.1024.
Increased activation of lymphocytes in inflammatory bowel disease is reflected by alterations of various immunological functions including enhanced spontaneous secretion of rheumatoid factor by mononuclear cells. since in rheumatic diseases increased secretion of rheumatoid factor is associated with decreased levels of beta-endorphin in circulating blood mononuclear leukocytes, we investigated levels of leukocyte beta-endorphin in inflammatory bowel disease and compared them with those in hepatobiliary disorders and in healthy subjects. Levels of beta-endorphin were measured in extracts from peripheral blood mononuclear leukocytes by radioimmunoassay. beta-Endorphin levels ranged from 0 to 67 pg/10(6) cells. Mononuclear leukocytes from ulcerative colitis patients contained as much beta-endorphin as those from healthy control subjects. In patients with Crohn's disease, levels of beta-endorphin were reduced by as much as roughly 50%. An inverse relationship was found between leukocyte beta-endorphin on the one hand and erythrocyte sedimentation rate, blood granulocyte or thrombocyte counts, and C-reactive protein levels in plasma on the other. In patients with various hepatobiliary disorders including fatty liver disease, viral hepatitis, primary biliary cirrhosis, and cryptogenic or alcoholic cirrhosis, beta-endorphin levels were not significantly different from the normal range values. Data indicate that leukocyte beta-endorphin may be involved in regulation of the systemic inflammatory activity of Crohn's disease.
炎症性肠病中淋巴细胞活化增加表现为各种免疫功能的改变，包括单核细胞类风湿因子自发分泌增强。由于在风湿性疾病中，类风湿因子分泌增加与循环血单核白细胞中β-内啡肽水平降低有关，我们研究了炎症性肠病中白细胞β-内啡肽水平，并将其与肝胆疾病患者及健康受试者的水平进行比较。采用放射免疫分析法测定外周血单核白细胞提取物中的β-内啡肽水平。β-内啡肽水平在0至67 pg/10⁶细胞之间。溃疡性结肠炎患者的单核白细胞所含β-内啡肽与健康对照受试者的相当。克罗恩病患者的β-内啡肽水平降低了约50%。一方面发现白细胞β-内啡肽与另一方面的红细胞沉降率、血粒细胞或血小板计数以及血浆C反应蛋白水平之间呈负相关。在患有各种肝胆疾病（包括脂肪肝、病毒性肝炎、原发性胆汁性肝硬化以及隐源性或酒精性肝硬化）的患者中，β-内啡肽水平与正常范围值无显著差异。数据表明，白细胞β-内啡肽可能参与克罗恩病全身炎症活动的调节。
