Sacerdote P, di San Secondo V E, Sirchia G, Manfredi B, Panerai A E
Department of Pharmacology, University of Milano, Italy.
Clin Exp Immunol. 1998 Sep;113(3):465-9. doi: 10.1046/j.1365-2249.1998.00680.x.
The continuous infusion of the opioid peptide beta-endorphin prolongs skin allograft survival in mice, while the opiate receptor antagonist naloxone, administered together with the opioid at the time of transplantation, abolishes the effect of the opioid. Consistently, naloxone, when given alone at the time of transplantation, but not later, accelerates graft rejection and increases splenocyte IL-2 and interferon-gamma (IFN-gamma) production. Splenocyte beta-endorphin concentrations are lower in transplanted animals. The effects of exogenous beta-endorphin and naloxone suggest that the endogenous opioid peptide beta-endorphin exerts a tonic inhibitory effect over early events of T cell-mediated immune responses in vivo. The effects of beta-endorphin and naloxone are consistent with the previously shown role of the opioid system in the modulation of the Th1/Th2 cytokine pattern.
持续输注阿片肽β-内啡肽可延长小鼠皮肤同种异体移植的存活时间，而在移植时与阿片类药物一起给予的阿片受体拮抗剂纳洛酮则可消除阿片类药物的作用。同样，纳洛酮在移植时单独给予（而非之后给予）会加速移植物排斥反应，并增加脾细胞白细胞介素-2和干扰素-γ（IFN-γ）的产生。移植动物的脾细胞β-内啡肽浓度较低。外源性β-内啡肽和纳洛酮的作用表明，内源性阿片肽β-内啡肽在体内对T细胞介导的免疫反应的早期事件发挥着持续的抑制作用。β-内啡肽和纳洛酮的作用与先前显示的阿片系统在调节Th1/Th2细胞因子模式中的作用一致。
