Koch T R, Roddy D R, Go V L
Am J Gastroenterol. 1987 Apr;82(4):321-6.
Peptide YY has been localized within human ileocolonic endocrine cells and may contribute to the regulation of gastric secretion and gastric emptying in man. Since our previous studies had shown decreased colonic concentrations of peptide YY in the idiopathic inflammatory bowel diseases, a specific radioimmunoassay was used to measure fasting serum concentrations of peptide YY in healthy controls and in patients with adenocarcinoma of the rectum, idiopathic chronic active liver disease and hepatic cirrhosis, ulcerative colitis, and Crohn's disease. In healthy controls and in patients with adenocarcinoma of the rectum, serum concentrations of peptide YY ranged from 50 to 260 pg/ml. Serum concentrations of peptide YY in patients with hepatic cirrhosis ranged from 59 to 717 pg/ml. Serum concentrations of peptide YY in patients with ulcerative colitis were similar to healthy controls. In patients with Crohn's disease, serum concentrations of peptide YY were less than 50 pg/ml in three patients who had had a previous proctocolectomy, and were more than 260 pg/ml in 14 patients who had had previous resection of more than 48 cm of ileum or presently had symptomatic Crohn's disease subsequently requiring surgical resection of a total of more than 75 cm of ileum. These results suggest that most circulating peptide YY is released from the colorectal region. Hepatic cirrhosis, previous ileal resection, and symptomatic Crohn's disease were associated with elevation of fasting serum peptide YY. The mechanism of increased fasting serum peptide YY in patients with Crohn's disease could be the loss of an ileal inhibitory factor or possibly an increased release of colonic peptide YY in response to fat malabsorption. The effect of alteration of serum peptide YY concentrations on the pathophysiology of Crohn's disease is yet unknown.
肽YY已定位在人回结肠内分泌细胞内，可能参与人体胃分泌和胃排空的调节。由于我们之前的研究表明，特发性炎症性肠病患者结肠中肽YY浓度降低，因此我们使用特异性放射免疫分析法来测定健康对照者以及患有直肠癌、特发性慢性活动性肝病和肝硬化、溃疡性结肠炎和克罗恩病患者的空腹血清肽YY浓度。健康对照者和直肠癌患者的血清肽YY浓度范围为50至260 pg/ml。肝硬化患者的血清肽YY浓度范围为59至717 pg/ml。溃疡性结肠炎患者的血清肽YY浓度与健康对照者相似。在克罗恩病患者中，3例曾接受直肠结肠切除术的患者血清肽YY浓度低于50 pg/ml，14例曾切除超过48 cm回肠或目前患有症状性克罗恩病且随后需要手术切除总计超过75 cm回肠的患者血清肽YY浓度高于260 pg/ml。这些结果表明，大多数循环中的肽YY是从结直肠区域释放的。肝硬化、既往回肠切除术和症状性克罗恩病与空腹血清肽YY升高有关。克罗恩病患者空腹血清肽YY升高的机制可能是回肠抑制因子的丧失，或者可能是结肠肽YY因脂肪吸收不良而释放增加。血清肽YY浓度改变对克罗恩病病理生理学的影响尚不清楚。
