Shen L, Du J Y, Yang J Y
Xiehe Hospital, Tongji Medical University, Wuhan.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1994 Sep;14(9):515-8.
The effect of Bushen Migu Ye (BSMGY) on preventing the bone loss in postmenopausal women was observed. 43 healthy women with the menopause within 5 years were randomly divided into the treated and control groups, which were basically similar in age and menopausal time. BSMGY and Rhizoma Dioscoreae decoction was given orally in two groups. Some biochemical parameters related to bone metabolism, serum estradiol and forearm bone density were taken before and after treatment. The results showed that 5 months after BSMGY treatment, the ulnar and radial bone mineral content was higher than that of pretreatmental value (P < 0.05), while in control group this index was continually decreased. The change in bone density were also significant different (P < 0.05). It seems that BSMGY is able to prevent the bone loss in postmenopausal women. In the treated group, ratio of fasting urinary calcium and hydroxyproline to creatinine was lower than that of before treatment and the control group (P < 0.05); the concentration of serum alkaline phosphatase had no significant difference (P < 0.05). This preliminary study suggested that one of the therapeutic mechanism of BSMGY was probably due to declining of bone resorption, without affecting the bone formation in postmenopausal women.
观察补肾密骨液（BSMGY）对绝经后妇女预防骨质流失的作用。将43名绝经5年内的健康女性随机分为治疗组和对照组，两组年龄和绝经时间基本相似。两组均口服补肾密骨液和山药汤剂。治疗前后检测一些与骨代谢相关的生化指标、血清雌二醇和前臂骨密度。结果显示，补肾密骨液治疗5个月后，尺桡骨矿物质含量高于治疗前（P<0.05），而对照组该指标持续下降。骨密度变化也有显著差异（P<0.05）。似乎补肾密骨液能够预防绝经后妇女的骨质流失。治疗组空腹尿钙、羟脯氨酸与肌酐的比值低于治疗前及对照组（P<0.05）；血清碱性磷酸酶浓度无显著差异（P<0.05）。这项初步研究表明，补肾密骨液的治疗机制之一可能是由于绝经后妇女骨吸收下降，而不影响骨形成。
