Bridges P K, Bartlett J R, Hale A S, Poynton A M, Malizia A L, Hodgkiss A D
UMDS, Guy's Hospital, London.
Br J Psychiatry. 1994 Nov;165(5):599-611; discussion 612-3. doi: 10.1192/bjp.165.5.599.
Stereotactic subcaudate tractotomy (SST) is the only type of psychosurgery performed at the Geoffrey Knight Unit, London, where nearly 1300 operations have been done since 1961. Statistically reliable data are not available to prove the effectiveness of SST. A detailed statement about contemporary psychosurgery is given.
Relevant publications from the Unit and via Medline are discussed. The outcome figures are reviewed. The outcome is assessed at the Unit in global and clinical terms, associated with results of self-completed questionnaires.
SST allows 40-60% of patients to live normal or near-normal lives, perhaps with continuation of medication. A reduction in suicide rate to 1% post-operatively, from 15% in cases of uncontrolled affective disorders is seen.
As a treatment of last resort, no controlled trial against a comparable treatment is possible. It appears reasonable to offer SST to patients with suicidal and deluded depression or with frequently swinging moods, not responding to other treatments.
立体定向尾状核下束切断术(SST)是伦敦杰弗里·奈特神经外科中心开展的唯一一种精神外科手术,自1961年以来已进行了近1300例手术。目前尚无统计学上可靠的数据来证明SST的有效性。本文给出了关于当代精神外科手术的详细说明。
讨论了该中心及通过医学在线数据库(Medline)获取的相关出版物。对结果数据进行了回顾。该中心从整体和临床角度对结果进行评估,并结合患者自行填写问卷的结果。
SST使40%至60%的患者能够过上正常或接近正常的生活,可能仍需继续服药。术后自杀率从情感障碍未得到控制病例中的15%降至1%。
作为一种最后的治疗手段,无法与类似治疗方法进行对照试验。对于有自杀倾向、妄想性抑郁或情绪频繁波动且对其他治疗无反应的患者,提供SST治疗似乎是合理的。