Frick T J, Olsen W A
Medical Service, William S. Middleton Memorial Veterans Hospital, Madison, WI.
Gastroenterologist. 1994 Dec;2(4):285-92.
Celiac disease is a well-known entity in which intolerance to wheat gluten and related proteins from barley, rye, and oats (collectively known as prolamins) damage intestinal mucosa. New insights into the pathology of the celiac intestinal lesion point to a wider spectrum of gluten sensitivity than previously thought. Recent advances in immunology and genetics have shed light on the underlying mechanisms and risks associated with the disease. Although the classical manifestations are well known, the wide variety of clinical presentations make celiac disease often difficult to diagnose, and the ubiquitous presence of prolamins in the Western diet make treatment challenging.
乳糜泻是一种已知的疾病，对小麦麸质以及来自大麦、黑麦和燕麦的相关蛋白质（统称为醇溶蛋白）不耐受会损害肠道黏膜。对乳糜泻肠道病变病理学的新见解表明，麸质敏感性的范围比以前认为的更广。免疫学和遗传学的最新进展揭示了与该疾病相关的潜在机制和风险。尽管经典表现众所周知，但乳糜泻多种多样的临床表现常常使其难以诊断，而且西方饮食中醇溶蛋白无处不在，这使得治疗具有挑战性。
