Atterhög J H, Ekelund L G, Melin A L
Eur J Clin Pharmacol. 1975 Feb 28;8(2):125-30. doi: 10.1007/BF00561561.
To test if nifedipine, 10 mg sublingually, could increase exercise tolerance, ten patients with angina pectoris each performed two types of bicycle exercise test, one with a stepwise increase in load and the other with a continuously increasing load. The drug was given in a double-blind cross-over trial. Nifedipine raised the heart rate and diminished the systemic blood pressure at rest, on standing and during exercise at comparable loads. Work time was prolonged and higher work loads were achieved. The total work performed rose by 50 per cent in one of the tests and by 23 per cent in the other, about 50 minutes after taking the drug. The mechanism of the greater work capacity in angina pectoris after nifedipine was assumed to be diminished heart work due to a fall in systemic vascular resistance.
为了测试舌下含服10毫克硝苯地平是否能提高运动耐量，10名心绞痛患者每人进行了两种类型的自行车运动试验，一种是负荷逐步增加，另一种是负荷持续增加。该药物在双盲交叉试验中给药。硝苯地平在静息、站立及同等负荷运动时均能提高心率并降低体循环血压。运动时间延长，且能达到更高的工作负荷。服药后约50分钟，在其中一项试验中总工作量增加了50%，在另一项试验中增加了23%。硝苯地平治疗后心绞痛患者工作能力增强的机制被认为是由于体循环血管阻力下降导致心脏做功减少。
