Ford W H, Ashworth L A, Inder S
Eur J Immunol. 1976 Feb;6(2):135-8. doi: 10.1002/eji.1830060213.
The production of migration inhibition (MIF) and mitogenic (MF) factors by cultured guinea pig lymph node cells was examined as a function of the concentration of antigen or concanavalin A (ConA). Maximum output of MIF was achieved at comparatively low levels of antigen and was equal to the maximum output by ConA. In contrast, MF output increased up to the highest antigen concentrations tested. Kinetic and chromatographic analysis revealed no differences between the MF produced at high and low antigen concentration.
研究了培养的豚鼠淋巴结细胞产生迁移抑制因子（MIF）和促有丝分裂因子（MF）的情况，作为抗原或伴刀豆球蛋白A（ConA）浓度的函数。在相对较低的抗原水平下，MIF产量达到最大值，且与ConA产生的最大产量相当。相比之下，MF产量在测试的最高抗原浓度下仍持续增加。动力学和色谱分析表明，高抗原浓度和低抗原浓度下产生的MF没有差异。
