van 't Veen A J, van Joost T
Department of Dermatovenerology, Erasmus University Rotterdam, Academic Hospital Rotterdam-Dijkzigt, The Netherlands.
Contact Dermatitis. 1994 Nov;31(5):293-8. doi: 10.1111/j.1600-0536.1994.tb02022.x.
The results on thimerosal (Merthiolate) hypersensitivity of a retrospective study, together with the relevant data on thimerosal hypersensitivity referred to in the literature up to 1993, are presented. Positive patch test reactions to thimerosal (0.1% pet.) were observed in 32 (1.3%) of 2461 adult patients with suspected contact allergy examined in the period 1987-1992. 20 (0.8%) patients had a solitary positive patch test to thimerosal. The observed incidence is low. Clinical symptoms related to thimerosal hypersensitivity were observed in only 3 patients. The collected results are discussed with emphasis on the clinical implications of sensitization to thimerosal. It appears that a positive patch test to thimerosal is frequently clinically irrelevant.
本文呈现了一项关于硫柳汞（硫柳汞）超敏反应的回顾性研究结果，以及截至1993年文献中提及的硫柳汞超敏反应的相关数据。在1987年至1992年期间接受检查的2461例疑似接触性过敏的成年患者中，有32例（1.3%）对硫柳汞（0.1% 凡士林制剂）的斑贴试验呈阳性反应。20例（0.8%）患者对硫柳汞的斑贴试验呈孤立阳性。观察到的发病率较低。仅在3例患者中观察到与硫柳汞超敏反应相关的临床症状。对收集到的结果进行了讨论，重点是硫柳汞致敏的临床意义。似乎对硫柳汞的斑贴试验阳性在临床上常常无关紧要。
