Lijnen P, Petrov V, Amery A
Hypertension Unit, Campus Gasthuisberg, Leuven, Belgium.
Eur J Clin Pharmacol. 1994;47(3):281-3. doi: 10.1007/BF02570509.
In vitro incubation of human erythrocytes and platelets with the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor pravastatin in the concentration range 1 nM to 10 microM did not affect the activity of the Na(+)-K(+)-pump, Na(+)-K(+)-cotransport or Na(+)-Li(+)-countertransport, or the ground membrane leak for Na+ and K+. The data indicate that pravastatin has no direct effect on transmembrane cationic transport systems in red blood cells or platelets.
在1纳摩尔至10微摩尔浓度范围内，用3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂普伐他汀对人红细胞和血小板进行体外孵育，并未影响钠钾泵、钠钾协同转运或钠锂逆向转运的活性，也未影响钠和钾的基底膜渗漏。数据表明，普伐他汀对红细胞或血小板中的跨膜阳离子转运系统没有直接影响。
