基于平衡氨基酸的饮食对四氯化碳诱导的肝损伤中氮代谢的影响。
Effect of a balanced amino acid-based diet on the nitrogen metabolism in carbon tetrachloride-induced liver injury.
作者信息
Sarafov D, Mitkov D, Dzhambazova S
机构信息
Department of Physiology, University of Medicine, Plovdiv, Bulgaria.
出版信息
Folia Med (Plovdiv). 1994;36(1):13-20.
In experimental study, in white rats with carbon tetrachloride-induced injury of the liver, branched-chain amino acids of vegetable origin were found to display hepatoprotective activity against the CCL4 toxic effect. They reduced the ammonia and glutamine concentrations in the blood and brains of the experimental animals and caused a significant decrease in the concentration of the aromatic amino acids (phenylalanine and tyrosine) in the animals' brains. The results of the study indicate that branched-chain amino acids are related to the pathogenesis of hepatic encephalopathy.
在实验研究中，在四氯化碳诱导肝脏损伤的白鼠中，发现植物来源的支链氨基酸对四氯化碳的毒性作用具有肝脏保护活性。它们降低了实验动物血液和大脑中的氨和谷氨酰胺浓度，并使动物大脑中芳香族氨基酸（苯丙氨酸和酪氨酸）的浓度显著降低。研究结果表明，支链氨基酸与肝性脑病的发病机制有关。
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