Dash S C, Sundaram K R, Swain P K
Department of Nephrolohgy, All India Institute of Medical Sciences, New Delhi.
J Assoc Physicians India. 1994 Nov;42(11):878-80.
Blood pressure and nutritional profiles in the 'Oraon' tribal community of India living in rural and urban areas were studied between 1981-85 after a house to house survey of 4523 rural tribal people (RT) and 935 of their urban tribal counterparts (UT). Prevalence of hypertension was found to be 4.8/1000 males and 4.3/1000 females in rural tribal group giving an overall rate of 4.6/1000. In contrast the same were 27.1/1000 males and 21.4/1000 females in UT group, overall rate being 25.6/1000. Average calorie consumption were 1750 and 2280 and mean 24 hour-urinary sodium excretions 58 and 118 milliequivalents in RT and UT groups respectively. Of the total of 21 subjects in RT and 24 in UT detected to be hypertensive, 7 had common family inheritance. Increased mean arterial pressure correlated with increased sodium consumption and body weight. Hypertensives from both the groups showed higher urinary sodium excretion (P < 0.05). This epidemiologic study proves the role of a genetic factor/defect complicated by higher salt consumption in causation of increased blood pressure.
1981年至1985年间，在对4523名农村部落居民（RT）及其935名城市部落居民（UT）进行逐户调查后，对居住在印度农村和城市地区的“奥拉昂”部落社区的血压和营养状况进行了研究。农村部落组中高血压患病率为男性4.8/1000，女性4.3/1000，总体患病率为4.6/1000。相比之下，UT组中男性患病率为27.1/1000，女性患病率为21.4/1000，总体患病率为25.6/1000。RT组和UT组的平均卡路里摄入量分别为1750和2280，24小时尿钠平均排泄量分别为58和118毫当量。在RT组检测出的21名高血压患者和UT组检测出的24名高血压患者中，有7人有共同的家族遗传史。平均动脉压升高与钠摄入量增加和体重增加相关。两组高血压患者的尿钠排泄量均较高（P<0.05）。这项流行病学研究证明了遗传因素/缺陷在高盐摄入的影响下，在血压升高的病因中所起的作用。
