DeLisi C, Metzger H
Immunol Commun. 1976;5(5):417-36. doi: 10.3109/08820137609033858.
Quantitative evaluations of a variety of binding reactions of interest to immunologists have usually assumed that the reactants are homogenously dispersed in solution for purposes of calculation. In fact, many of these reactions involve cell-bound "receptors" which are present at exceedingly high local concentrations on discrete particles. We describe how such a distribution can influence the experimentally measured binding constants. We also briefly consider the additional complexities introduced when multipoint attachment between the ligand and cell-bound receptors is possible, and discuss the possible biological implications.
免疫学家感兴趣的各种结合反应的定量评估通常假定，为了计算目的，反应物在溶液中是均匀分散的。事实上，这些反应中的许多都涉及细胞结合的“受体”，它们以极高的局部浓度存在于离散的颗粒上。我们描述了这种分布如何影响实验测量的结合常数。我们还简要考虑了配体与细胞结合受体之间可能发生多点附着时引入的额外复杂性，并讨论了可能的生物学意义。
