初次免疫应答中的特异性细胞刺激：一种量化模型。
Specific cellular stimulation in the primary immune response: a quantized model.
作者信息
Vogelstein B, Dintzis R Z, Dintzis H M
出版信息
Proc Natl Acad Sci U S A. 1982 Jan;79(2):395-9. doi: 10.1073/pnas.79.2.395.
Abstract
A general theory for the initial phase of T cell independent immune response is derived from elementary physical-chemical considerations and from the premise that response entails a quantized linkage of cell surface receptors. The theory leads to the construction of explicit antigen dose--response and antigen dose--suppression curves, to the calculation of intrinsic affinities for receptors, and to the deduction that receptors are divalent in character. The theory may be applicable to other cell surface phenomena wherein requirements for stimulation and suppression are equivalent to those found in the immune system.
摘要
一种关于非T细胞依赖性免疫反应初始阶段的通用理论，源自基本的物理化学考量以及反应需要细胞表面受体进行量化连接这一前提。该理论促使构建明确的抗原剂量-反应曲线和抗原剂量-抑制曲线，计算受体的内在亲和力，并推断出受体具有二价特性。该理论可能适用于其他细胞表面现象，其中刺激和抑制的要求与免疫系统中的要求相当。
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