Kaup F J, Kuhn E M, Makoschey B, Hunsmann G
Working Group of Experimental Pathology, F.R.G..
J Med Primatol. 1994 Jul;23(5):304-8. doi: 10.1111/j.1600-0684.1994.tb00288.x.
Following an experimental SIV infection, 11 rhesus monkeys were evaluated to determine the presence of opportunistic infections. Five animals had severe alterations of the hepatobiliary tree, three of which were associated with the presence of numerous Cryptosporidium spp. Subacute to chronic inflammatory changes were observed in the pancreatic ducts of four animals, one without histologic evidence of parasites. In one animal, the inflamed ducts were associated with a chronic interstitial pancreatitis. The rate of Cryptosporidium infection together with hepatic and pancreatic involvement (36%) supports the hypothesis that systemic cryptosporidiosis is the result of a loss of protective mucosal immunity.
在进行实验性猴免疫缺陷病毒（SIV）感染后，对11只恒河猴进行评估以确定是否存在机会性感染。5只动物出现了肝胆树的严重改变，其中3只与大量隐孢子虫属的存在有关。在4只动物的胰管中观察到亚急性至慢性炎症变化，其中1只没有寄生虫的组织学证据。在1只动物中，发炎的导管与慢性间质性胰腺炎有关。隐孢子虫感染率以及肝脏和胰腺受累情况（36%）支持系统性隐孢子虫病是保护性黏膜免疫丧失的结果这一假说。
