Yanai T, Chalifoux L V, Mansfield K G, Lackner A A, Simon M A
Vet Pathol. 2000 Sep;37(5):472-5. doi: 10.1354/vp.37-5-472.
Cryptosporidiosis is a common opportunistic infection in the gastrointestinal tract of human and nonhuman primates with AIDS. Pulmonary infection associated with Cryptosporidium spp. has not been previously reported in monkeys. Two macaques experimentally infected with simian immunodeficiency virus (SIV) had lesions containing cryptosporidial organisms involving the trachea, lungs, bile ducts, pancreas, and intestine. The pulmonary sections revealed moderate to severe bronchopneumonia associated with cryptosporidiosis. Numerous 2-4 microm oval Cryptosporidium spp. organisms were present in the cytoplasm of alveolar macrophages, multinucleated giant cells, and intestinal epithelial cells. Giant cells were positive for SIV by in situ hybridization. These are the first reported cases of cryptosporidiosis with involvement of pulmonary parenchyma in SIV-infected macaques.
隐孢子虫病是人类和感染艾滋病的非人灵长类动物胃肠道常见的机会性感染。此前尚未有猴子感染隐孢子虫属导致肺部感染的报道。两只经实验感染猿猴免疫缺陷病毒（SIV）的猕猴，其病变部位含有隐孢子虫生物体，累及气管、肺、胆管、胰腺和肠道。肺部切片显示伴有隐孢子虫病的中度至重度支气管肺炎。在肺泡巨噬细胞、多核巨细胞和肠道上皮细胞的细胞质中存在大量2 - 4微米椭圆形的隐孢子虫属生物体。通过原位杂交检测，巨细胞呈SIV阳性。这些是首次报道的SIV感染猕猴并发累及肺实质的隐孢子虫病病例。
