Clemmons Elizabeth A, Jean Sherrie M, Machiah Deepa K, Breding Eileen, Sharma Prachi
Division of Animal Resources, School of Medicine, Emory University, Atlanta, Georgia, USA.
Division of Pathology, Yerkes National Primate Research Center, School of Medicine, Emory University, Atlanta, Georgia, USA.
Comp Med. 2014 Dec;64(6):496-500.
Two cases of clinical disease associated with extraintestinal Campylobacter infection were recently encountered in rhesus macaques (Macaca mulatta). The first case was that of a 3-y-old, male, rhesus macaque experimentally infected with SIV, who presented with abdominal pain and a midabdominal mass and was euthanized. Pathology findings included an abscess within the median liver lobe, fibrinopurulent peritonitis, and intestinal serositis with isolation of Campylobacter fetus from the blood, liver, and the hepatic abscess. The second case was that of a 1-mo-old, female, rhesus macaque who died with no apparent history of illness. Gross pathology findings included thin body condition and diarrheic staining of the perineum; histologically, acute multifocal hepatitis with intralesional bacteria was noted. Campylobacter coli was isolated from the liver and colon. Extraintestinal Campylobacter infection is uncommon in humans, usually occurring in immunocompromised subjects and most commonly manifesting as bacteremia. Extraintestinal Campylobacter infections in animals are rare but have been associated with bacteremia and cholecystitis. The macaques presented here were either immunocompromised due to SIV infection (case 1) or more vulnerable due to young age (case 2). These factors likely contributed to the extraintestinal spread of Campylobacter.
最近在恒河猴（猕猴属）中遇到了两例与肠外弯曲杆菌感染相关的临床疾病病例。第一例是一只3岁的雄性恒河猴，经实验感染了猴免疫缺陷病毒（SIV），它出现腹痛和中腹部肿块后被安乐死。病理检查结果包括肝中叶脓肿、纤维蛋白脓性腹膜炎和肠浆膜炎，并且从血液、肝脏和肝脓肿中分离出胎儿弯曲杆菌。第二例是一只1个月大的雌性恒河猴，无明显疾病史死亡。大体病理检查结果包括身体消瘦和会阴区腹泻样污渍；组织学检查发现急性多灶性肝炎，病灶内有细菌。从肝脏和结肠中分离出结肠弯曲杆菌。肠外弯曲杆菌感染在人类中并不常见，通常发生在免疫功能低下的个体中，最常见的表现为菌血症。动物中的肠外弯曲杆菌感染很少见，但与菌血症和胆囊炎有关。这里呈现的恒河猴要么因感染SIV而免疫功能低下（病例1），要么因年龄小而更易感染（病例2）。这些因素可能促成了弯曲杆菌的肠外传播。
