San L, Fernandez T, Cami J, Gossop M
Sección de Toxicomanías, Hospital del Mar, Barcelona, Spain.
J Subst Abuse Treat. 1994 Sep-Oct;11(5):463-9. doi: 10.1016/0740-5472(94)90100-7.
In a randomized double-blind study, the clinical efficacy of methadone vs. methadone and guanfacine was assessed in terms of evolution of opioid withdrawal symptoms during inpatient detoxification. A total of 144 patients were included and randomly allocated to three different treatment groups: methadone alone, and two combined treatment schedules (methadone plus 3 or 4 mg of guanfacine). No differences were observed among the three groups with regard to retention rate throughout the study period. Both therapies, methadone and methadone plus guanfacine, determined a slight increase in withdrawal scores when methadone was discontinued. However, guanfacine was unable to effectively control methadone-associated withdrawal symptoms. These results indicate that guanfacine does not effectively reduce the opioid withdrawal symptoms.
在一项随机双盲研究中，就住院戒毒期间阿片类药物戒断症状的演变情况，对美沙酮与美沙酮加胍法辛的临床疗效进行了评估。总共纳入了144名患者，并将其随机分配到三个不同的治疗组：单独使用美沙酮组，以及两个联合治疗方案组（美沙酮加3毫克或4毫克胍法辛）。在整个研究期间，三组的留存率未观察到差异。美沙酮疗法和美沙酮加胍法辛疗法在停用美沙酮时，均使戒断评分略有增加。然而，胍法辛无法有效控制与美沙酮相关的戒断症状。这些结果表明，胍法辛不能有效减轻阿片类药物戒断症状。
