[Fibromyalgia. A neuro-immuno-endocrinologic syndrome?].

Fibromyalgia is an enigmatic long-lasting polysymptomatic disease which has been thought to be caused by peripheral muscle dysfunction or psychological factors. Based on a clinical evaluation of a large series of in-patients and a review of international findings, the article advances the hypothesis of irreversible disturbances of the neuroimmunoendocrinological system as the main cause of this disease. The therapeutic consequences of this hypothesis are discussed.