Rejeski W J, Shumaker S
Department of Health & Sport Science, and Public Health Sciences, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27109.
Med Sci Sports Exerc. 1994 Dec;26(12):1441-5.
This section of the symposium addresses the definition, measurement, and relevance of health-related quality of life (HRQL) to osteoarthritis (OA) of the knee. Emphasis is placed on the multidimensional nature of HRQL and the fact that these measures can be used as either outcome or process variables. Clearly, HRQL has been accepted as an appropriate measure of treatment efficacy (an outcome measure) in most clinical research, augmenting the more traditional measures of morbidity and mortality. However, as this paper demonstrates, HRQL measures constitute important process variables in understanding disability and related concepts that are critical in designing effective therapies for treating knee OA.
本次研讨会的这一部分讨论了健康相关生活质量（HRQL）对膝关节骨关节炎（OA）的定义、测量及其相关性。重点在于HRQL的多维性质以及这些测量可作为结果变量或过程变量使用这一事实。显然，在大多数临床研究中，HRQL已被公认为衡量治疗效果的适当指标（一种结果指标），它补充了更为传统的发病率和死亡率指标。然而，正如本文所表明的，HRQL测量在理解残疾及相关概念方面构成重要的过程变量，而这些概念对于设计治疗膝关节OA的有效疗法至关重要。
