Apinun Jirun, Sengprasert Panjana, Yuktanandana Pongsak, Ngarmukos Srihatach, Tanavalee Aree, Reantragoon Rangsima
Department of Orthopedics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Immunology Division, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Int J Rheumatol. 2016;2016:9525724. doi: 10.1155/2016/9525724. Epub 2016 Dec 14.
Osteoarthritis is a condition of joint failure characterized by many pathologic changes of joint-surrounding tissues. Many evidences suggest the role of both innate and adaptive immunity that interplay, resulting either in initiation or in progression of osteoarthritis. Adaptive immune cells, in particular T cells, have been demonstrated to play a role in the development of OA in animal models. However, the underlying mechanism is yet unclear. Our aim was to correlate the frequency and phenotype of tissue-infiltrating T cells in the synovial tissue and infrapatellar fat pad with radiographic grading. Our results show that CD8+ T cells are increased in osteoarthritic patients with higher radiographic grading. When peripheral blood CD8+ T cells were examined, we show that CD8+ T cells possess a significantly higher level of activation than its CD4+ T cell counterpart ( < 0.0001). Our results suggest a role for CD8+ T cells and recruitment of these activated circulating peripheral blood CD8+ T cells to the knee triggering local inflammation within the knee joint.
骨关节炎是一种关节功能衰竭病症，其特征为关节周围组织出现多种病理变化。许多证据表明，先天性免疫和适应性免疫相互作用，在骨关节炎的起始或进展过程中发挥作用。在动物模型中，已证实适应性免疫细胞，尤其是T细胞，在骨关节炎的发展中发挥作用。然而，其潜在机制尚不清楚。我们的目的是将滑膜组织和髌下脂肪垫中组织浸润性T细胞的频率和表型与影像学分级相关联。我们的结果表明，在影像学分级较高的骨关节炎患者中，CD8 + T细胞数量增加。当检测外周血CD8 + T细胞时，我们发现CD8 + T细胞的活化水平明显高于其CD4 + T细胞对应物（<0.0001）。我们的结果表明，CD8 + T细胞发挥了作用，并且这些活化的循环外周血CD8 + T细胞募集到膝关节，引发膝关节内的局部炎症。
