Interspecies transmission of animal rotaviruses to humans as evidenced by phylogenetic analysis of the hypervariable region of the VP4 protein.

A phylogenetic tree constructed for the hypervariable region (aa 71-203) of the VP4 protein of 28 human and animal rotaviruses that were previously reported to belong to 13 distinct VP4 genotypes revealed unique positions of human rotavirus strains HCR3 and Ro1845, together with feline strain FRV64 and canine strains K9 and CU-1, in the animal rotavirus lineages, lending strong support to the view that both HCR3 and Ro1845 were of animal rotavirus origin.