Schramm L, Heidbreder E, Schaar J, Lopau K, Zimmermann J, Götz R, Ling H, Heidland A
Medical Clinic, University of Würzburg, Germany.
Nephron. 1994;68(4):454-61. doi: 10.1159/000188307.
Beneficial effects of natriuretic peptides have been reported in different models of acute renal failure (ARF). Calcium antagonists can also improve renal function, especially in ischemic models of ARF. The aim of our study was to investigate the effects of urodilatin and diltiazem alone and in combination in uranyl nitrate-induced toxic ARF in the rat. Three hours after induction of ARF glomerular filtration rate (GFR) was clearly diminished to about 50% compared to basal values. Intravenous infusion of diltiazem and urodilatin revealed a significant increase of GFR that even continued after cessation of drug delivery. Combined administration of urodilatin and diltiazem had no additional effect, probably due to a more pronounced fall in blood pressure in this group. Besides their vasorelaxing and blood pressure lowering effects both drugs also revealed diuretic activity. In conclusion both urodilatin and diltiazem are able to elevate GFR in the early phase of toxic ARF in the rat.
利钠肽在不同的急性肾衰竭（ARF）模型中已被报道具有有益作用。钙拮抗剂也可改善肾功能，尤其是在ARF的缺血模型中。我们研究的目的是探讨单独及联合应用尿舒张素和地尔硫䓬对硝酸铀酰诱导的大鼠中毒性ARF的影响。在诱导ARF三小时后，肾小球滤过率（GFR）与基础值相比明显降低至约50%。静脉输注地尔硫䓬和尿舒张素显示GFR显著增加，甚至在停止给药后仍持续。尿舒张素和地尔硫䓬联合给药没有额外效果，可能是由于该组血压下降更为明显。除了血管舒张和降压作用外，两种药物还显示出利尿活性。总之，尿舒张素和地尔硫䓬均能够在大鼠中毒性ARF的早期提高GFR。
