Lindenmayer J P, Bernstein-Hyman R, Grochowski S, Bark N
Department of Psychiatry, Albert Einstein College of Medicine/Montefiore Medical Center, New York, N.Y.
Psychopathology. 1995;28(1):22-31. doi: 10.1159/000284896.
Schizophrenic psychopathology is heterogeneous and multidimensional. One of the more fruitful strategies to investigate more homogenous domains of psychopathology has been the positive-negative syndrome approach. However, this approach is unable to address a number of important issues. Most schizophrenics present a mixed syndrome; the criteria for what constitutes a positive and negative syndrome are variable; distinguishing primary from secondary negative symptoms can be difficult. In order to address some of these problems, we propose the introduction of a 5-syndrome model based on a reanalysis of factor-analytic procedures used on 240 schizophrenics assessed with the Positive and Negative Syndrome Scale: A negative, positive, excitement, cognitive and depression/anxiety factor. This 5-factor solution is supported by 4 independent and comparable factor analyses. Data on internal consistency of the 5 factors and on initial validation using demographic and clinical variables are presented.
精神分裂症的精神病理学是异质性且多维度的。研究更具同质性的精神病理学领域的一种较为有效的策略是阳性-阴性综合征方法。然而，这种方法无法解决一些重要问题。大多数精神分裂症患者呈现混合综合征；构成阳性和阴性综合征的标准是可变的；区分原发性阴性症状和继发性阴性症状可能很困难。为了解决其中一些问题，我们提议引入一种基于对240名使用阳性和阴性综合征量表评估的精神分裂症患者进行因素分析程序重新分析的五综合征模型：一个阴性、阳性、兴奋、认知和抑郁/焦虑因素。这一五因素解决方案得到了4项独立且可比的因素分析的支持。文中呈现了这5个因素的内部一致性数据以及使用人口统计学和临床变量进行初步验证的数据。
