Sucharzewska-Tomczak M, Grzegorzewska A
Kliniki Nefrologii Akademii Medycznej im. Karola Marcinkowskiego w Poznaniu.
Przegl Lek. 1994;51(7):300-2.
The effect of furosemide (1500 mg/21 of peritoneal dialysis fluid) on excretion of hydroxyproline in dialysate and its renal clearance was investigated in 12 patients with end-stage renal disease on regular dialysis treatment. The 37 +/- 8% and 20 +/- 6% increase of D/S ratio of hydroxyproline after 5 and 8 hours of dwell, respectively, and 52 +/- 24% increase of renal clearance of hydroxyproline were induced by furosemide, which indicate its significant influence on peritoneal and renal removal of hydroxyproline.
在12例接受定期透析治疗的终末期肾病患者中，研究了呋塞米（1500毫克/21份腹膜透析液）对透析液中羟脯氨酸排泄及其肾脏清除率的影响。呋塞米分别使羟脯氨酸在留置5小时和8小时后的D/S比值增加37±8%和20±6%，并使羟脯氨酸的肾脏清除率增加52±24%，这表明其对腹膜和肾脏清除羟脯氨酸有显著影响。
