Arvill A, Bodin L
Department of Clinical Physiology and Occupational Medicine, Orebro Medical Centre Hospital, Sweden.
Am J Clin Nutr. 1995 Mar;61(3):585-9. doi: 10.1093/ajcn/61.3.585.
The effects of the soluble fiber konjac glucomannan (GM) on serum cholesterol concentrations were investigated in 63 healthy men in a double-blind crossover, placebo-controlled study. After a 2-wk baseline period, the subjects were given 3.9 g GM or placebo daily for 4 wk. After a washout period of 2 wk, crossover took place, followed by another 4 wk of treatment. The subjects were encouraged not to change their ordinary diets or general lifestyle during the investigation. GM fibers reduced total cholesterol (TC) concentrations by 10% (P < 0.0001), low-density-lipoprotein cholesterol (LDL-C) concentrations by 7.2% (P < 0.007), triglycerides by 23% (P < 0.03), and systolic blood pressure by 2.5% (P < 0.02). High-density-lipoprotein cholesterol (HDL-C) and the ratio of LDL-C to HDL-C did not change significantly. No change in diastolic blood pressure or body weight was observed. No adverse effects were observed. The results of this study show that GM is an effective cholesterol-lowering dietary adjunct.
在一项双盲交叉、安慰剂对照研究中，对63名健康男性研究了可溶性纤维魔芋葡甘聚糖（GM）对血清胆固醇浓度的影响。在为期2周的基线期后，受试者每天服用3.9克GM或安慰剂，持续4周。经过2周的洗脱期后，进行交叉，随后再进行4周的治疗。在调查期间，鼓励受试者不要改变其日常饮食或总体生活方式。GM纤维使总胆固醇（TC）浓度降低了10%（P<0.0001），低密度脂蛋白胆固醇（LDL-C）浓度降低了7.2%（P<0.007），甘油三酯降低了23%（P<0.03），收缩压降低了2.5%（P<0.02）。高密度脂蛋白胆固醇（HDL-C）以及LDL-C与HDL-C的比值没有显著变化。未观察到舒张压或体重的变化。未观察到不良反应。本研究结果表明，GM是一种有效的降胆固醇饮食辅助剂。
