Liu L, Sakamoto S, Nakayama T, Kudo H, Suzuki S, Matsubara M, Nagasawa H
Medical Research Institute, Tokyo Medical and Dental University, Japan.
Am J Chin Med. 1994;22(3-4):267-74. doi: 10.1142/S0192415X94000322.
Sho-saiko-to (SST) is a Japanese modified, traditional Chinese herbal medicine (Kampo medicine) consisting of seven medical plants. We examined the effects of SST on formation and growth of squamous cell papillomas induced by 7,12-dimethylbenz(a)anthracene application in mouse skin. Chronic oral administration of SST reduced the incidence and growth of papillomas with the reduction of activities of succinate-dehydrogenase and thymidylate synthetase, which were evaluated as the cell viability and DNA synthesis via the de novo pathway, respectively.
小柴胡汤（SST）是一种改良的日本传统中药（汉方医学），由七种药用植物组成。我们研究了小柴胡汤对7,12-二甲基苯并(a)蒽诱导的小鼠皮肤鳞状细胞乳头瘤形成和生长的影响。长期口服小柴胡汤可降低乳头瘤的发生率和生长速度，同时琥珀酸脱氢酶和胸苷酸合成酶的活性降低，这两种酶分别通过从头合成途径评估细胞活力和DNA合成。
