Sakamoto S, Mori T, Sawaki K, Kawachi Y, Kuwa K, Kudo H, Suzuki S, Sugiura Y, Kasahara N, Nagasawa H
Medical Research Institute, Tokyo Medical and Dental University, Japan.
Planta Med. 1993 Apr;59(2):152-4. doi: 10.1055/s-2006-959632.
Sho-Saiko-To (SST) is a modified Japanese traditional Chinese herbal medicine containing seven medical plants: Bupleuri radix, Pinelliae tuber, Suxtallariae radix, Zizyphi fructus, Ginseng radix, Glycyrrhizae radix, and Zingiberis recens rhizoma. This preparation has been used in the treatment of some inflammatory diseases of the respiratory system and chronic hepatitis. In the present study, the effects of SST were investigated on the activities of DNA-synthesizing enzymes in 1,2-dimethylhydrazine (DMH)-induced colonic carcinomas in rats. Six-week administration of SST prevented nearly 100% of the body weight loss and the final number of the colonic carcinomas compared to those in the rats treated with DMH alone, and suppressed the enhanced activities of thymidylate synthetase (TS) and thymidine kinase (TK) which were involved in the de novo and salvage pathways of pyrimidine synthesis, respectively, in DMH-induced colonic carcinomas. These results indicate that SST may show directly and/or indirectly inhibitory effects on the development of colonic carcinomas.
小柴胡汤（SST）是一种改良的日本传统中药，含有七种药用植物：柴胡、半夏、党参、大枣、人参、甘草和生姜。这种制剂已用于治疗一些呼吸系统炎症性疾病和慢性肝炎。在本研究中，研究了SST对1,2-二甲基肼（DMH）诱导的大鼠结肠癌中DNA合成酶活性的影响。与单独用DMH处理的大鼠相比，六周给予SST可预防近100%的体重减轻和结肠癌的最终数量，并抑制了DMH诱导的结肠癌中分别参与嘧啶合成的从头合成途径和补救途径的胸苷酸合成酶（TS）和胸苷激酶（TK）的活性增强。这些结果表明，SST可能对结肠癌的发展具有直接和/或间接的抑制作用。
