Poller L, Triplett D A, Hirsh J, Carroll J, Clarke K
Department of Pathological Sciences, Medical School, University of Manchester, UK.
Am J Clin Pathol. 1995 Mar;103(3):366-71. doi: 10.1093/ajcp/103.3.366.
The comparative value of lyophilized artificially depleted plasmas and plasmas from warfarin-treated patients in local (thromboplastin/coagulometer) system International Sensitivity Indices (ISI) determination has been studied at 39 centers in an international collaborative study. At each center, both types of plasmas were tested with two common thromboplastins (low ISI RecombiPlasTin and high ISI OBT), and in-house reagents using three brands of coagulometers. In 95 local systems, they was agreement. With both thromboplastins, coagulometers lowered the ISI from the manual or stated ISI with all systems. Differences between the two types of lyophilized plasmas with the two common thromboplastins were not of clinical importance. Artificially depleted plasmas are easier to obtain in sufficient volumes than plasma from warfarin-treated patients, and more easily provide the wide range of INR values required for reliable local ISI calibration. The agreement between the two types of lyophilized calibrant is reassuring.
在一项国际合作研究中，39个中心对冻干人工去除某些成分的血浆和华法林治疗患者的血浆在局部（凝血活酶/凝血仪）系统国际敏感度指数（ISI）测定中的比较价值进行了研究。在每个中心，两种类型的血浆都使用两种常见的凝血活酶（低ISI的重组凝血活酶和高ISI的OBT）以及使用三个品牌凝血仪的内部试剂进行检测。在95个局部系统中，结果一致。使用这两种凝血活酶时，凝血仪均降低了所有系统手动或规定ISI的数值。两种类型的冻干血浆与两种常见凝血活酶之间的差异不具有临床重要性。人工去除某些成分的血浆比华法林治疗患者的血浆更容易获得足够的量，并且更容易提供可靠的局部ISI校准所需的广泛国际标准化比值（INR）值。两种类型的冻干校准品之间的一致性令人放心。
