Friedlander M A, Wu Y C, Schulak J A, Monnier V M, Hricik D E
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH.
Am J Kidney Dis. 1995 Mar;25(3):445-51. doi: 10.1016/0272-6386(95)90107-8.
Plasma and tissue concentrations of pentose-derived glycation end-products ("pentosidine") are elevated in diabetic patients with normal renal function and in both diabetic and nondiabetic patients with end-stage renal disease. To determine the influence of dialysis modality and other clinical variables on the accumulation of pentosidine, we used high-performance liquid chromatography to measure this advanced glycation end-product in plasma, skin, and peritoneal samples obtained from 65 hemodialysis and 45 peritoneal dialysis patients. Plasma pentosidine levels were significantly lower in peritoneal dialysis patients. Concentrations of pentosidine in skin were similar in the two groups. In contrast, peritoneal concentrations of pentosidine were significantly higher in the patients maintained on peritoneal dialysis. Our results demonstrate that dialysis modality influences the plasma and tissue distribution of pentosidine. Compared with hemodialysis, peritoneal dialysis is associated with lower levels of this glycation end-product in plasma, but with higher levels in the peritoneum. The mechanisms accounting for lower circulating levels of pentosidine in peritoneal dialysis patients remain to be determined. Higher levels in peritoneal tissues may reflect chronic exposure to the high concentrations of glucose in peritoneal dialysate.
在肾功能正常的糖尿病患者以及患有终末期肾病的糖尿病和非糖尿病患者中，源自戊糖的糖基化终产物（“戊糖苷”）的血浆和组织浓度均会升高。为了确定透析方式和其他临床变量对戊糖苷蓄积的影响，我们使用高效液相色谱法测量了从65名血液透析患者和45名腹膜透析患者获取的血浆、皮肤和腹膜样本中的这种晚期糖基化终产物。腹膜透析患者的血浆戊糖苷水平显著更低。两组患者皮肤中的戊糖苷浓度相似。相比之下，接受腹膜透析的患者腹膜中的戊糖苷浓度显著更高。我们的结果表明，透析方式会影响戊糖苷的血浆和组织分布。与血液透析相比，腹膜透析与血浆中这种糖基化终产物水平较低相关，但与腹膜中水平较高相关。腹膜透析患者循环中戊糖苷水平较低的机制仍有待确定。腹膜组织中较高的水平可能反映了长期暴露于腹膜透析液中的高浓度葡萄糖。
