Veber B
Service de Réanimation des maladies infectieuses, Hôpital Bichat, Claude-Bernard, Paris.
Ann Fr Anesth Reanim. 1994;13(4):457-9. doi: 10.1016/s0750-7658(05)80671-9.
In order to avoid the risk of severe infection by bacterial contamination of propofol, all users of this agent, should be reminded of the required aseptic technique "for the correct use of Diprivan". These points have recently been listed by Zeneca Pharma. They mainly include the following items: 1. Propofol is to be administered immediately after opening the vials and/or ampoules and the duration of the same continuous infusion should not excede 12 hours. 2. Disposable equipment (syringes, infusion sets, 3-way stopcoks, infusion bottles) should be used and restricted to one patient only. 3. One ampoule or vial of diprivan, once opened, must be used for one patient only. The remaining solution must be discarded. 4. Disinfection of the ampoule neck or vial stopper using and antiseptic solution before opening, is a strongly measure recommended. 5. Finally, hand washing should be routine, prior to these manipulations. As far as the above mentioned precautions are strictly followed, this anaesthetic agent may be used safely, even in case of prolonged sedation.
为避免因丙泊酚细菌污染而导致严重感染的风险，所有使用该药物的人员均应牢记“正确使用得普利麻”所需的无菌技术。阿斯利康制药公司最近列出了这些要点。主要包括以下几点：1. 打开安瓿瓶和/或小瓶后应立即使用丙泊酚，同一持续输注的时长不应超过12小时。2. 应使用一次性设备（注射器、输液器、三通旋塞、输液瓶），且仅限用于一名患者。3. 一支得普利麻安瓿瓶或小瓶一旦打开，必须仅用于一名患者。剩余溶液必须丢弃。4. 强烈建议在打开之前使用消毒剂溶液对安瓿瓶颈部或小瓶瓶塞进行消毒。5. 最后，在进行这些操作之前应常规洗手。只要严格遵循上述预防措施，即使在长时间镇静的情况下，这种麻醉剂也可安全使用。
