Warner L A, Kessler R C, Hughes M, Anthony J C, Nelson C B
Institute for Social Research, University of Michigan, Ann Arbor.
Arch Gen Psychiatry. 1995 Mar;52(3):219-29. doi: 10.1001/archpsyc.1995.03950150051010.
To analyze nationally representative data on the lifetime and 12-month prevalences of use of and dependence on illegal drugs (marijuana/hashish, cocaine/crack, heroin, hallucinogens), nonmedical prescription psychotropic drugs (sedatives, tranquilizers, stimulants, analgesics), and inhalants; and to examine data on the sociodemographic correlates of use and dependence.
The data come from the National Comorbidity Survey, a structured diagnostic interview administered to persons aged 15 to 54 years that generates reliable diagnoses according to the definitions and criteria of DSM-III-R.
Of the respondents, 51.0% used one of the above drugs at some time in their lives, and 15.4% did so in the past 12 months. These estimates are similar to those obtained in the 1991 National Household Survey of Drug Abuse, where lifetime prevalence was 45.2% and 12-month prevalence was 16.7% among respondents in the age range 15 to 54 years. Of National Comorbidity Survey respondents, 7.5% (14.7% of lifetime users) were dependent at some time in their lives and 1.8% were dependent in the past 12 months. The prevalence estimate for lifetime dependence was reduced to 5.3% when calculated the percentage of respondents in the age range of 28 to 54 years who reported an onset of dependence as of 10 years earlier (ie, when they were 18 to 44 years old) was computed. This is similar to the Epidemiologic Catchment Area Study estimate of 5.1% among respondents in the age range 18 to 44 years, a comparison that matches the two studies on year of assessment, age of risk, and cohort. Males were significantly more likely to report both lifetime and 12-month use and dependence. Use and dependence were found to be more common in cohorts born after World War II than those born before the end of the war. The demographic predictors of lifetime use differed from the predictors of lifetime dependence among users, and these, in turn, differed from the predictors of recent dependence among people with a lifetime history of dependence.
Drug use and dependence are highly prevalent in the general population. The fact that there are differences in the correlates of first use, dependence among users, and persistence of dependence means that future research aimed at pinpointing modifiable risk factors must be based on disaggregated analyses of separate stages of progression.
分析具有全国代表性的数据,以了解非法药物(大麻/哈希什、可卡因/快克、海洛因、致幻剂)、非医疗处方精神药物(镇静剂、 tranquilizers、兴奋剂、镇痛药)和吸入剂的终生使用率及12个月患病率,并研究使用和依赖的社会人口学相关因素的数据。
数据来自全国共病调查,这是一项对15至54岁人群进行的结构化诊断访谈,根据《精神疾病诊断与统计手册》第三版修订本(DSM-III-R)的定义和标准得出可靠的诊断结果。
在受访者中,51.0%的人在其生命中的某个时候使用过上述药物之一,15.4%的人在过去12个月内使用过。这些估计值与1991年全国药物滥用家庭调查中的结果相似,在15至54岁的受访者中,终生患病率为45.2%,12个月患病率为16.7%。在全国共病调查的受访者中,7.5%(终生使用者中的14.7%)在生命中的某个时候有依赖,1.8%在过去12个月内有依赖。当计算28至54岁受访者中报告自10年前(即他们18至44岁时)开始依赖的比例时,终生依赖的患病率估计降至5.3%。这与流行病学集水区研究中18至44岁受访者中5.1%的估计值相似,这种比较在评估年份、风险年龄和队列方面使两项研究相匹配。男性报告终生和12个月使用及依赖的可能性显著更高。发现二战后出生的队列中使用和依赖比战争结束前出生的队列更为普遍。终生使用的人口统计学预测因素与使用者中终生依赖的预测因素不同,而这些又与有终生依赖史的人群中近期依赖的预测因素不同。
药物使用和依赖在普通人群中非常普遍。首次使用、使用者中的依赖以及依赖持续存在的相关因素存在差异这一事实意味着,未来旨在确定可改变风险因素的研究必须基于对进展的不同阶段进行分类分析。