Machado F de A, Collares E F
Universidade Federal de Uberlândia.
Arq Gastroenterol. 1994 Apr-Jun;31(2):57-62.
The gastric emptying of sucrose and maltose solutions at different concentrations, with addition of phenol red (6 mg%) used as a marker, was studied in 144 Wistar male rats. The gastric retention was determined 15 minutes after the orogastric infusion of sucrose and maltose solutions at 2.5%, 5% and 10% and volume of 1 and 2 ml/100 g weight of the animal, making 1 use of 12 rats for each volume and concentration. The activities of lactase, sucrase and maltase were evaluated in other eight rat's small intestine. The results demonstrated a maltase/sucrase activity rate of 4:1. The gastric retentions of the maltose solution were significantly higher than sucrose solution at 10% and 5% concentration, either 1 and 2 ml/100 g weight. There were no differences between gastric retention at 2.5% concentration neither with 2 nor 1 ml/100 g weight. As an explanation of these results it is proposed that the faster gastric emptying of sucrose solution 10% and 5% in relation with the same concentrations of maltose is due to a probable saturation of sucrase, that when achieved, interrupts the regulation of gastric emptying, determined by the intestinal receptors.
在144只雄性Wistar大鼠中，研究了添加酚红（6mg%）作为标记物的不同浓度蔗糖和麦芽糖溶液的胃排空情况。在经口胃内注入2.5%、5%和10%的蔗糖和麦芽糖溶液（体积为1和2ml/100g动物体重）15分钟后测定胃潴留量，每种体积和浓度使用12只大鼠。在另外8只大鼠的小肠中评估乳糖酶、蔗糖酶和麦芽糖酶的活性。结果显示麦芽糖酶/蔗糖酶活性率为4:1。在10%和5%浓度下，无论是1ml/100g体重还是2ml/100g体重，麦芽糖溶液的胃潴留量均显著高于蔗糖溶液。在2.5%浓度下，无论是2ml/100g体重还是1ml/100g体重，胃潴留量均无差异。对于这些结果的解释是，10%和5%的蔗糖溶液相对于相同浓度的麦芽糖溶液胃排空更快，这可能是由于蔗糖酶可能饱和，一旦达到饱和，就会中断由肠道受体决定的胃排空调节。
