Wolfe N, Reed B R, Eberling J L, Jagust W J
Department of Neurology, University of California, Davis-Northern California Alzheimer's Disease Center, Berkeley.
Arch Neurol. 1995 Mar;52(3):257-62. doi: 10.1001/archneur.1995.00540270049018.
To examine the ability of relative regional cerebral blood flow as measured by single photon emission computed tomography to predict longitudinal course of cognitive decline in Alzheimer's disease.
Single photon emission computed tomography using the blood flow tracer 123I-N-isopropyl-p-iodoamphetamine was performed at initial evaluation and was used to predict the rate of cognitive decline over a follow-up period from 1 to 4 years.
Outpatient university dementia clinic and center for functional imaging.
Twenty-nine patients met National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria for probably or possible AD.
Temporal lobe regional cerebral blood flow ratio at initial evaluation correlated with rate of decline in Mini-Mental State Examination over the longitudinal follow-up. Temporal regional cerebral blood flow ratio also predicted rate of decline of specific memory measures on the California Verbal Learning Test. Neither parietal nor frontal ratios predicted rate of cognitive decline. Dorsolateral frontal hypoperfusion was associated with the emergence of perseverative behaviors over time. Age, prior dementia duration, estimated prior rate of decline, and initial severity did not predict rate of cognitive decline.
Results suggest that regional perfusion on single photon emission computed tomography may predict cognitive decline in Alzheimer's disease better than these demographic and course variables.
研究通过单光子发射计算机断层扫描测量的相对局部脑血流量预测阿尔茨海默病认知衰退纵向病程的能力。
在初始评估时进行使用血流示踪剂123I-N-异丙基-p-碘安非他明的单光子发射计算机断层扫描，并用于预测1至4年随访期内的认知衰退率。
大学门诊痴呆诊所和功能成像中心。
29名患者符合美国国立神经疾病与中风研究所-阿尔茨海默病及相关疾病协会可能或疑似AD的标准。
初始评估时的颞叶局部脑血流量比值与纵向随访期间简易精神状态检查的衰退率相关。颞叶局部脑血流量比值还可预测加利福尼亚言语学习测试中特定记忆指标的衰退率。顶叶和额叶比值均不能预测认知衰退率。背外侧额叶灌注不足与持续行为随时间出现有关。年龄、既往痴呆持续时间、估计的既往衰退率和初始严重程度均不能预测认知衰退率。
结果表明，单光子发射计算机断层扫描的局部灌注可能比这些人口统计学和病程变量能更好地预测阿尔茨海默病的认知衰退。
