Craig A H, Cummings J L, Fairbanks L, Itti L, Miller B L, Li J, Mena I
Department of Neurology, University of California, Los Angeles, USA.
Arch Neurol. 1996 Nov;53(11):1116-20. doi: 10.1001/archneur.1996.00550110056012.
Apathy is a pervasive noncognitive neuropsychiatric disturbance in Alzheimer disease, which causes significant caregiver distress. The neuroanatomical substrate of apathy is not well understood.
To study the relationship between regional cerebral blood flow and the presence and severity of the personality disturbance, apathy, in individuals with Alzheimer disease.
Analysis of the relationship between regional cerebral blood flow as measured by single photon emission computed tomography and severity of apathy as measured by the Neuropsychiatric Inventory using an analysis of variance design. We examined regional cerebral perfusion alterations as measured by xenon 133Xecalibrated technetium Tc 99m hexamethyl-propyleneamine-oxime single photon emission computed tomography in relation to the presence and severity of apathy.
The neurology clinics of the University of California, Los Angeles, UCLA School of Medicine, and Harbor-UCLA Medical Center.
Thirty-one community-dwelling patients fulfilling National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association diagnostic criteria for probable Alzheimer disease who had a single photon computed tomographic scan performed within 3 months of administration of the Neuropsychiatric Inventory.
The presence of apathy was associated with more severe prefrontal and anterior temporal dysfunction. These regional cerebral perfusion relationships with apathy were independent of cognitive decline except in the dorsolateral prefrontal cortex.
These results demonstrate the association of apathetic syndromes with prefrontal and anterior temporal regional brain dysfunction and are consistent with similar findings previously reported in other disorders.
淡漠是阿尔茨海默病中一种普遍存在的非认知性神经精神障碍，会给照料者带来极大困扰。目前对淡漠的神经解剖学基础尚不清楚。
研究阿尔茨海默病患者局部脑血流量与人格障碍、淡漠的存在及严重程度之间的关系。
采用方差分析设计，分析单光子发射计算机断层扫描测量的局部脑血流量与神经精神科问卷测量的淡漠严重程度之间的关系。我们研究了用氙133校准的锝Tc 99m六甲基丙烯胺肟单光子发射计算机断层扫描测量的局部脑灌注改变与淡漠的存在及严重程度之间的关系。
加利福尼亚大学洛杉矶分校、洛杉矶加州大学医学院和哈伯-加州大学洛杉矶分校医学中心的神经科门诊。
31名符合美国国立神经疾病与中风研究所-阿尔茨海默病及相关疾病协会可能阿尔茨海默病诊断标准的社区居住患者，他们在接受神经精神科问卷评估后3个月内进行了单光子计算机断层扫描。
淡漠的存在与更严重的前额叶和颞叶前部功能障碍相关。除背外侧前额叶皮质外，这些局部脑灌注与淡漠的关系独立于认知功能下降。
这些结果表明淡漠综合征与前额叶和颞叶前部区域脑功能障碍有关，与先前在其他疾病中报道的类似发现一致。
