Naito K, Senoh Y, Ishihara M, Takeda N, Ibata K, Yokoyama N, Iwata S
Department of Otolaryngology, Fujita Health University School of Medicine, Aichi, Japan.
Auris Nasus Larynx. 1994;21(3):158-62. doi: 10.1016/s0385-8146(12)80138-6.
We previously reported that, in a patient with Japanese cedar pollinosis, preseasonal increase in total nasal airway resistance (NAR) possibly caused from circannual endogenous rhythm was suppressed by preseasonal systemic administration of antiallergic agent. In this study, in order to determine the influence of preseasonal use of a topical antiallergic agent and seasonal administration of a peroral antiallergic agent, we made measurement of nasal airway resistance and pollen counts under the previous respective conditions in separated years. Preseasonal high mean values of total NAR for a couple of weeks was not suppressed by the preseasonal topical administration of ketotifen nasal spray in 1992 which was a low pollen season (974/cm2). However, the patient did not complained of severe episodes of hay fever at all throughout the season. Preseasonal increases in mean values of total NAR were observed in 1993 which was a high Japanese cedar pollen season (4,875/cm2) with NAR the same as untreated seasons. This may have been because the patient was not treated with preseasonal use of peroral azelastine. On extremely high Japanese cedar pollen count days further increased NAR occurred in the patient. The patient experienced relatively severe hay fever episodes, but used no other anti-histamine nor topical steroid during the season.
我们之前报道过，在一名日本雪松花粉症患者中，季节性前鼻总气道阻力（NAR）的增加可能是由年度内源性节律引起的，而季节性前全身给予抗过敏药物可抑制这种增加。在本研究中，为了确定季节性前使用局部抗过敏药物和季节性给予口服抗过敏药物的影响，我们在不同年份的先前各自条件下测量了鼻气道阻力和花粉计数。在花粉量少的季节（974/cm²）的1992年，季节性前几周总NAR的高平均值未被季节性前局部使用酮替芬鼻喷雾剂所抑制。然而，该患者在整个季节根本没有抱怨过严重的花粉热发作。在花粉量多的日本雪松花粉季节（4875/cm²）的1993年观察到季节性前总NAR平均值增加，且NAR与未治疗季节相同。这可能是因为该患者未接受季节性前口服氮卓斯汀治疗。在日本雪松花粉计数极高的日子里，该患者的NAR进一步增加。该患者经历了相对严重的花粉热发作，但在该季节未使用其他抗组胺药或局部类固醇。
