西洋参皂苷（PQS）及其单体人参皂苷对心脏的影响

[The effects of Panax quinquefolium saponin (PQS) and its monomer ginsenoside on heart].

作者信息

Chen X, Yang S J, Chen L, Ma X L, Chen Y P, Wang L L, Sun C W

机构信息

Norman Bethune University of Medical Sciences, Changchun.

出版信息

Zhongguo Zhong Yao Za Zhi. 1994 Oct;19(10):617-20, 640.

PMID:7873084

Abstract

Experiments have shown that PQS (0.03-3 mg/ml) can inhibit the contractility of papillary muscle of guinea pigs, and on depolarized sample of papillary muscle with high potassium, PQS (0.03-0.3 mg/ml) can increase this contractility. Monomer saponin-Re (10 mg/kg),-Rb3 (30 mg/kg) can inhibit the hemodynamic indication of rats, but pseudogisenoside-F11 (10 mg/kg) acts the other way round. These results prove that PQS contains two components of opposite actions.

摘要

实验表明，PQS（0.03 - 3毫克/毫升）可抑制豚鼠乳头肌的收缩力，而在高钾去极化的乳头肌样本上，PQS（0.03 - 0.3毫克/毫升）可增强这种收缩力。单体皂苷Re（10毫克/千克）、Rb3（30毫克/千克）可抑制大鼠的血流动力学指标，但假人参皂苷-F11（10毫克/千克）则作用相反。这些结果证明PQS含有两种作用相反的成分。