Fukuda M, Morimoto T, Matsuda H, Nagao H, Wakamoto H, Ohnishi A
Department of Pediatrics, School of Medicine, Ehime University.
No To Hattatsu. 1995 Jan;27(1):41-6.
We reported a 6-year-old girl with acute idiopathic pandysautonomia (AIPD) associated with syndrome of inappropriate secretion of anti-diuretic hormone (SIADH). She showed various symptoms indicating the impairment of widespread sympathetic and parasympathetic nervous functions and SIADH, which followed common cold. Sural nerve biopsy showed severe reduction of both myelinated and unmyelinated fibers. The main site of the lesion of AIPD has been assumed to be the peripheral autonomic nervous system. However, there are a few reports indicating the involvement of the central nervous system in AIPD. The present case also indicates the involvement of hypothalamus in addition to the peripheral autonomic nervous system.
我们报告了一名6岁女孩，患有急性特发性全自主神经功能不全（AIPD）并伴有抗利尿激素分泌不当综合征（SIADH）。她出现了各种症状，提示广泛的交感和副交感神经功能以及SIADH受损，这些症状发生在普通感冒之后。腓肠神经活检显示有髓和无髓纤维均严重减少。AIPD的主要病变部位被认为是外周自主神经系统。然而，有一些报告表明中枢神经系统也参与了AIPD。本病例除了外周自主神经系统外，还提示下丘脑也受到了累及。
