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编码一种起始因子2相关蛋白（p67）的人类互补DNA的分子克隆。

Molecular cloning of a human complementary DNA encoding an initiation factor 2-associated protein (p67).

作者信息

Li X, Chang Y H

机构信息

Edward A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, MO 63104.

出版信息

Biochim Biophys Acta. 1995 Feb 21;1260(3):333-6. doi: 10.1016/0167-4781(94)00227-t.

DOI:10.1016/0167-4781(94)00227-t
PMID:7873610
Abstract

Rat p67 is an initiation factor-2 associated protein, which plays important roles in translational regulation. A cDNA that encodes a homologue of rat p67 was isolated from a human liver cDNA library. The encoded protein contains 478 amino acids with a calculated molecular mass of 52,891 and an isoelectric point of 5.64. The amino acid sequence is 92% identical to that of rat p67. The corresponding mRNA has a size of approximately 2.1 kb and is present in all tested human tissues.

摘要

大鼠p67是一种与起始因子-2相关的蛋白质，在翻译调控中发挥重要作用。从人肝脏cDNA文库中分离出一个编码大鼠p67同源物的cDNA。编码的蛋白质含有478个氨基酸，计算分子量为52,891，等电点为5.64。其氨基酸序列与大鼠p67的氨基酸序列有92%的同一性。相应的mRNA大小约为2.1 kb，存在于所有检测的人体组织中。

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