[米托蒽醌对体内染色质DNA作用的微量量热研究]
[Microcalorimetric study of the effect of mitoxantrone on chromatin DNA in vivo].
作者信息
Monaselidze D R, Kalandadze Ia L, Khachidze D G, Topuridze I
出版信息
Biofizika. 1994 Nov-Dec;39(6):1004-8.
PMID:7873619
Abstract
The influence of antitumor drugs--mitocsantron on the chromatine of tumor cells spleen tissue of BALB/c-mice has been established. Two-stage denaturation process of chromatine in normal cells has been shown. The first stage--thermolabel domain can be described by the following transition parameters: Td1 = 72, delta Td1 = 6.2 degrees C, Qd1 = 36.5 J/g DNA; the second one-thermostable domain by Td2 = 83, delta Td2 = 9.0 degrees C kappa Qd2 = 58 J/g DNA.
摘要
已经确定了抗肿瘤药物米托蒽醌对BALB/c小鼠肿瘤细胞脾组织染色质的影响。研究显示了正常细胞中染色质的两阶段变性过程。第一阶段——热敏感结构域可由以下转变参数描述：Td1 = 72，ΔTd1 = 6.2℃，Qd1 = 36.5 J/g DNA；第二阶段——热稳定结构域由Td2 = 83，ΔTd2 = 9.0℃，κQd2 = 58 J/g DNA描述。
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