Asakawa F, Jitsunari F, Shiraishi H, Suna S, Takeda N, Manabe Y
Department of Hygiene and Public Health, Kagawa Medical School.
Nihon Koshu Eisei Zasshi. 1994 Nov;41(11):1084-9.
Chlordane concentrations were analyzed in the adipose tissue of mice after prolonged inhalation of low levels of chlordanes in indoor air. After inhalation of 4.22-11.36 micrograms/m3 chlordanes (total of 5 compounds) in air for 1-6 months, high levels of chlordanes (4.19-11.63 ppm, total of 5 compounds and 2 metabolites) were found in the adipose tissue. Transnanochlor, which accounted for only 14% of the total chlordane in the inhaled air, showed a high percentage (50%) in the adipose tissue, followed by 2 metabolites, i.e., oxychlordane (25%) and heptachlorepoxide (22%). Little transchlordane, cis-chlordane, or heptachlor, which accounted for high percentages of the total chlordane inhaled, was detected in the adipose tissue. A low level of cis-nonachlor was observed in the adipose tissue, and its percentage was similar to that in the air (2%). The level of chlordane exposure and the adipose tissue chlordane concentration was closely correlated (r = 0.9077, p < 0.01), showed a dose-effect relationship. These findings suggest that chlordanes such as trans-nonachlor, oxychlordane, and heptachlorepoxide may accumulate in the adipose tissue of people living in an environment containing even low levels of chlordanes and that there is a risk from indoor air contamination by chlordanes.
在室内空气中长期吸入低水平氯丹后，对小鼠脂肪组织中的氯丹浓度进行了分析。在空气中吸入4.22 - 11.36微克/立方米氯丹（共5种化合物）1 - 6个月后，在脂肪组织中发现了高水平的氯丹（4.19 - 11.63 ppm，共5种化合物和2种代谢物）。反式毒杀芬在吸入空气中仅占总氯丹的14%，但在脂肪组织中所占比例很高（50%），其次是2种代谢物，即氧氯丹（25%）和七氯环氧化物（22%）。在脂肪组织中几乎未检测到吸入的总氯丹中占比很高的反式氯丹、顺式氯丹或七氯。在脂肪组织中观察到低水平的顺式九氯，其百分比与空气中的相似（2%）。氯丹暴露水平与脂肪组织中氯丹浓度密切相关（r = 0.9077，p < 0.01），呈现剂量效应关系。这些发现表明，诸如反式九氯、氧氯丹和七氯环氧化物等氯丹可能会在生活在即使含有低水平氯丹环境中的人的脂肪组织中蓄积，并且存在室内空气被氯丹污染的风险。
