Misawa H, Ohtsuka K, Nakata K, Kinoshita H
Department of Orthopaedic Surgery, School of Medicine, Shinshu University, Matsumoto, Japan.
J Spinal Disord. 1994 Dec;7(6):495-8.
We studied embryological development of the human spinal ligaments by dissecting 25 fetuses that ranged from 6 to 24 weeks of gestational age. At 6 and 7 weeks, the spine consisted of light zones and dark zones. The light zones were hypocellular and corresponded to vertebral bodies. The dark zones were hypercellular and corresponded to intervertebral disks. The anterior longitudinal ligament was identified at the gestational age of 8 weeks. At 10 weeks, the posterior longitudinal ligament was detected. At 12 weeks, laminae, the ligamentum flavum, and an ossification center were identified. At 15 weeks, fibers of the ligamentum flavum became clearer, but they were not as well as stained as the adult ligamentum flavum. The enthesis of the ligaments in the human fetuses was not completely identical to that in adults.
我们通过解剖25例胎龄在6至24周的胎儿，研究了人类脊柱韧带的胚胎发育情况。在6至7周时，脊柱由亮区和暗区组成。亮区细胞较少，对应椎体。暗区细胞较多，对应椎间盘。前纵韧带在孕8周时可辨认。在孕10周时，检测到后纵韧带。在孕12周时，可辨认出椎板、黄韧带和一个骨化中心。在孕15周时，黄韧带的纤维变得更清晰，但染色效果不如成人黄韧带。人类胎儿韧带的附着点与成人的并不完全相同。
