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颈椎黄韧带的综合综述。

Comprehensive review of the cervical ligamenta flava.

作者信息

Mortell Tatjana, Mortezaei Ali, Samrid Rarinthorn, Keshavarzi Sassan, Inoue Seiichi, Kikuchi Keishiro, Iwanaga Joe, Dumont Aaron S, Tubbs R Shane

机构信息

Tulane University School of Medicine, New Orleans, LA, USA.

Gonabad University of Medical Sciences, Gonabad, Iran.

出版信息

Surg Radiol Anat. 2025 Apr 1;47(1):109. doi: 10.1007/s00276-025-03615-x.

DOI:10.1007/s00276-025-03615-x
PMID:40167761
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11961527/
Abstract

PURPOSE

The current literature contains many data associated with the cervical ligamentum flavum (CLF). The present study is to overview knowledge of CLF.

METHODS

Comprehensive literature review was performed.

RESULTS

Topics include anatomy, embryology, histology, radiology, clinical relevance, and pathological manifestations of the CLF, including ossification, calcification, and hypertrophy. Spine procedures always require extreme precision; spine surgeons and neurosurgeons encounter challenges that put patients' lives at risk.

CONCLUSION

This study can assist clinicians in performing spinal interventions with the fewest possible complications. Because there have been few studies of the CLF, further investigation is suggested.

摘要

目的

当前文献包含许多与颈椎黄韧带(CLF)相关的数据。本研究旨在概述关于CLF的知识。

方法

进行了全面的文献综述。

结果

主题包括CLF的解剖学、胚胎学、组织学、放射学、临床相关性以及病理表现,包括骨化、钙化和肥大。脊柱手术始终需要极高的精准度;脊柱外科医生和神经外科医生面临着将患者生命置于危险境地的挑战。

结论

本研究可协助临床医生进行脊柱干预时尽可能减少并发症。由于对CLF的研究较少,建议进一步开展调查。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6eac/11961527/abc2d9c0dc78/276_2025_3615_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6eac/11961527/67b19f11d647/276_2025_3615_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6eac/11961527/abc2d9c0dc78/276_2025_3615_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6eac/11961527/67b19f11d647/276_2025_3615_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6eac/11961527/abc2d9c0dc78/276_2025_3615_Fig2_HTML.jpg

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1
Comprehensive review of the cervical ligamenta flava.颈椎黄韧带的综合综述。
Surg Radiol Anat. 2025 Apr 1;47(1):109. doi: 10.1007/s00276-025-03615-x.
2
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本文引用的文献

1
The cervical ligamentum flavum area: A new sensitive morphological parameter for identifying the cervical spinal stenosis.黄韧带颈椎区:一个新的敏感的形态学参数,用于识别颈椎椎管狭窄症。
Medicine (Baltimore). 2023 Nov 24;102(47):e36259. doi: 10.1097/MD.0000000000036259.
2
Integrative analysis of genome-wide DNA methylation and single-nucleotide polymorphism identified ACSM5 as a suppressor of lumbar ligamentum flavum hypertrophy.全基因组 DNA 甲基化和单核苷酸多态性的综合分析鉴定 ACSM5 为腰椎黄韧带肥厚的抑制因子。
Arthritis Res Ther. 2021 Sep 30;23(1):251. doi: 10.1186/s13075-021-02625-5.
3
CRLF1 Is a Key Regulator in the Ligamentum Flavum Hypertrophy.
CRLF1是黄韧带肥厚的关键调节因子。
Front Cell Dev Biol. 2020 Sep 18;8:858. doi: 10.3389/fcell.2020.00858. eCollection 2020.
4
Ossification of the ligamentum flavum.黄韧带骨化
Spine Surg Relat Res. 2017 Nov 27;1(4):158-163. doi: 10.22603/ssrr.1.2016-0031. eCollection 2017.
5
The Lumbar Ligamentum Flavum Does Not Have Two Layers and Is Confluent with the Interspinous Ligament: Anatomical Study with Application to Surgical and Interventional Pain Procedures.黄韧带无两层结构且与棘间韧带连续:一项应用于手术和介入性疼痛程序的解剖学研究。
Clin Anat. 2020 Jan;33(1):34-40. doi: 10.1002/ca.23437. Epub 2019 Aug 9.
6
Analysis of factors influencing ligamentum flavum thickness in lumbar spine - A radiological study of 1070 disc levels in 214 patients.腰椎黄韧带厚度影响因素分析——对214例患者1070个椎间盘层面的影像学研究
Clin Neurol Neurosurg. 2019 Jul;182:19-24. doi: 10.1016/j.clineuro.2019.04.023. Epub 2019 May 2.
7
Pathophysiology of Calcification and Ossification of the Ligamentum Flavum in the Cervical Spine.颈椎黄韧带钙化与骨化的病理生理学
Neurosurg Clin N Am. 2018 Jan;29(1):47-54. doi: 10.1016/j.nec.2017.09.016.
8
Anatomical analysis of human ligamentum flavum in the cervical spine: Special consideration to the attachments, coverage, and lateral extent.颈椎黄韧带的解剖学分析:对附着点、覆盖范围及外侧范围的特别考量
J Orthop Sci. 2017 Nov;22(6):994-1000. doi: 10.1016/j.jos.2017.07.008. Epub 2017 Aug 12.
9
Ossification of the Ligamentum Flavum as a Result of Fluorosis Causing Myelopathy: Report of Two Cases.氟中毒导致黄韧带骨化引起脊髓病:两例报告
Neurosurgery. 2005 Mar 1;56(3):E622. doi: 10.1227/01.NEU.0000154062.14313.6D.
10
Anatomical analysis of the relation between human ligamentum flavum and posterior spinal bony prominence.人体黄韧带与脊柱后骨性突起关系的解剖学分析
J Orthop Sci. 2017 Mar;22(2):260-265. doi: 10.1016/j.jos.2016.11.020. Epub 2016 Dec 23.