早产儿晚期贫血的输血治疗：对其他方面健康的婴儿的氧消耗、心率和体重增加的影响。

Blood transfusion in late anemia of prematurity: effect on oxygen consumption, heart rate, and weight gain in otherwise healthy infants.

作者信息

Böhler T, Janecke A, Linderkamp O

机构信息

Abteilung Neonatologie, Universitätskinderklinik Heidelberg, FRG.

出版信息

Infusionsther Transfusionsmed. 1994 Dec;21(6):376-9. doi: 10.1159/000223015.

DOI:10.1159/000223015

PMID:7873916

Abstract

BACKGROUND

In premature infants there is no universally accepted definition of anemia requiring transfusion. We designed the present investigation to study the effects of red blood cell transfusion (based on simple transfusion rules) on weight gain, energy metabolism, and heart rate in otherwise healthy preterm infants.

PATIENTS AND METHODS

We measured oxygen consumption (VO2), respiratory quotient (RQ) and energy expenditure (EE) by 4-hour indirect calorimetry, and assessed weight gain over 7 days and heart rate in 12 infants with late anemia of prematurity before and after red blood cell transfusion (10 ml/kg). At the time of transfusion, postmenstrual age was 38 +/- 1 weeks (mean +/- SEM), body weight 2.14 +/- 0.13 kg, and hemoglobin concentration 7.7 +/- 0.3 g/dl (range: 5.5-9.2).

RESULTS

Red blood cell transfusion increased the hemoglobin concentration by 3.8 +/- 0.5 g/dl, but had no significant effect on weight gain (15.4 +/- 2.4 vs. 13.8 +/- 1.8 g/kg/day), VO2 (8.7 +/- 0.3 vs. 8.7 +/- 0.3 ml/kg/min), minimal VO2 (7.2 +/- 0.3 vs. 7.7 +/- 0.4 ml/kg/min), RQ (0.96 +/- 0.02 vs. 0.95 +/- 0.02), EE (50 +/- 2 vs. 51 +/- 2 kcal/kg/day), and heart rate (160 +/- 3 vs. 158 +/- 3 min-1).

CONCLUSION

We conclude that oxygen supply and energy metabolism were not compromised in the anemic preterm infants at the time of red blood cell transfusion.

摘要

背景

对于需要输血的早产儿贫血，目前尚无普遍接受的定义。我们开展本研究以探讨红细胞输血（基于简单输血规则）对健康早产儿体重增加、能量代谢及心率的影响。

患者与方法

我们采用4小时间接测热法测量了12例晚期早产儿贫血患儿红细胞输血（10 ml/kg）前后的氧气消耗量（VO2）、呼吸商（RQ）及能量消耗（EE），并评估了7天内的体重增加及心率情况。输血时，月经后年龄为38±1周（均值±标准误），体重2.14±0.13 kg，血红蛋白浓度7.7±0.3 g/dl（范围：5.5 - 9.2）。

结果

红细胞输血使血红蛋白浓度升高了3.8±0.5 g/dl，但对体重增加（15.4±2.4 vs. 13.8±1.8 g/kg/天）、VO2（8.7±0.3 vs. 8.7±0.3 ml/kg/分钟）、最低VO2（7.2±0.3 vs. 7.7±0.4 ml/kg/分钟）、RQ（0.96±0.02 vs. 0.95±0.02）、EE（50±2 vs. 51±2 kcal/kg/天）及心率（160±3 vs. 158±3次/分钟）均无显著影响。