Zanin C, Béné M C, Perruchet A M, Perrin P, Martin F, Borelly J, Faure G C
Laboratoire d'Immunologie, Faculté de Médecine & Centre Hospitalier Universitaire de Nancy, France.
FEMS Immunol Med Microbiol. 1994 Nov;10(1):11-8. doi: 10.1111/j.1574-695X.1994.tb00005.x.
Bacterial ribosomes have been shown to induce effective humoral and cellular immunological responses to whole microorganisms. In this study, the numbers of specific antibody producing cells directed towards Klebsiella pneumoniae, Streptococcus pneumoniae, Streptococcus pyogenes and Haemophilus influenzae ribosomes or whole bacteria sonicates were compared in the peripheral blood and tonsils of 7 children, and in the tonsils, mesenteric and cervical lymph nodes of 10 sheep. No significant difference was noted between the two types of antigens, confirming that ribosomal preparations are able to mimic the immunogenicity of whole bacteria in the mucosae-associated lymphoid tissue.
已证明细菌核糖体可诱导针对完整微生物的有效体液免疫和细胞免疫反应。在本研究中，比较了7名儿童外周血和扁桃体以及10只绵羊扁桃体、肠系膜淋巴结和颈淋巴结中针对肺炎克雷伯菌、肺炎链球菌、化脓性链球菌和流感嗜血杆菌核糖体或全菌超声裂解物的特异性抗体产生细胞数量。两种抗原之间未观察到显著差异，证实核糖体制剂能够模拟完整细菌在黏膜相关淋巴组织中的免疫原性。
