Béné M C, Kahl L, Perruchet A M, Hermes H, Mösges M, Normier G, Binz H, Faure G C
Laboratoire d'Immunologie, Faculté de Médecine de Nancy, Vandoeuvre lès Nancy, France.
Scand J Immunol. 1993 Nov;38(5):496-8. doi: 10.1111/j.1365-3083.1993.tb02594.x.
A bacterial lysate (OM-85 BV), a preparation of purified bacterial ribosomes (D53) and a placebo were tested for ability to induce the local appearance of specific antibody-containing cells. The three compounds were given orally to 90 children who required tonsillectomy. Surgery was carried out after 1 month of therapy. Frozen-cut sections of each tonsil were tested in indirect immunofluorescence. Cells containing antibodies directed to Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae or Klebsiella pneumoniae were enumerated. Lowest values were noted in the placebo group. Slightly higher numbers were observed after treatment with OM-85 BV, but significant increases were noted only for the elevated numbers of specific antibody-containing cells observed after D53 therapy. Bacterial ribosomal preparations thus contribute efficient induction of specific local immune responses in man.
对一种细菌裂解物（OM-85 BV）、一种纯化的细菌核糖体制剂（D53）和一种安慰剂诱导含特异性抗体细胞局部出现的能力进行了测试。将这三种化合物口服给予90名需要进行扁桃体切除术的儿童。治疗1个月后进行手术。对每个扁桃体的冰冻切片进行间接免疫荧光检测。对含有针对肺炎链球菌、化脓性链球菌、流感嗜血杆菌或肺炎克雷伯菌抗体的细胞进行计数。安慰剂组的值最低。用OM-85 BV治疗后观察到的数量略高，但仅在D53治疗后观察到的含特异性抗体细胞数量显著增加。因此，细菌核糖体制剂有助于在人体中有效诱导特异性局部免疫反应。
