Kondo T, Liu F, Toda Y
Research Center of Health, Physical Fitness and Sports, Nagoya University, Japan.
J Gastroenterol. 1994 Dec;29(6):715-20. doi: 10.1007/BF02349276.
To improve and standardize the measurement of small bowel transit time, milk was employed for the test meal instead of the conventional lactulose meal. Although 92% of the subjects were lactase deficient, only 2% were milk intolerant and 13% were lactose intolerant. Small bowel transit time with milk (milk breath hydrogen test) was 113 +/- 9 min (mean +/- SE, n = 20); the normal range calculated from the mean +/- 2 SD was 31-195 min. The coefficient of variation in the milk hydrogen breath test was 13 +/- 4% (n = 6), whereas in the lactulose hydrogen breath test, it was 39 +/- 16% (n = 10). The frequency of non-hydrogen producers, the occurrence of discomfort, and the reproducibility were better, though not significantly so, in the milk hydrogen breath test than in the lactulose. Since lactase activity in the intestine is variable in lactase-deficient subjects, small bowel transit times for milk may change from subject to subject. However, individual reproducibility of the milk hydrogen breath test is good. It could be useful for pharmacological experiments using paired comparison, for screening tests, or for the follow up of diseases in which small bowel transit time is affected.
为了改进和规范小肠转运时间的测量，试验餐采用牛奶而非传统的乳果糖餐。尽管92%的受试者乳糖酶缺乏，但只有2%的人不耐受牛奶，13%的人乳糖不耐受。用牛奶进行小肠转运时间测定（牛奶呼气氢试验）为113±9分钟（平均值±标准误，n = 20）；根据平均值±2标准差计算的正常范围为31 - 195分钟。牛奶氢呼气试验的变异系数为13±4%（n = 6），而乳果糖氢呼气试验的变异系数为39±16%（n = 10）。在牛奶氢呼气试验中，非产氢者的频率、不适的发生率以及可重复性虽无显著差异，但比乳果糖氢呼气试验更好。由于乳糖酶缺乏受试者的肠道乳糖酶活性存在差异，不同受试者的牛奶小肠转运时间可能会有所不同。然而，牛奶氢呼气试验的个体可重复性良好。它可用于配对比较的药理实验、筛查试验或对小肠转运时间受影响疾病的随访。
