Wiley C A, Masliah E, Achim C L
University of Pittsburgh Medical Center, Department of Pathology, PA 15213-2582.
Adv Neuroimmunol. 1994;4(3):319-25. doi: 10.1016/s0960-5428(06)80272-x.
AIDS dementia complex affects between 20 and 30% of terminally ill AIDS patients. The histopathologic substrate of this clinical syndrome is chronic HIV infection of the nervous system termed HIV encephalitis. We hypothesize that the abundance and length of time that HIV is present in the CNS determines the severity of neurologic damage. We compared three different methods of assessing HIV burden in the CNS. While the assays vary in sensitivity, each provides a quantitative estimate of viral burden that can be compared between laboratories. Assays of provirus were readily divided into two groups, while protein assays showed a wider range. HIV-mediated neurotoxicity might be expected to more closely depend upon productive infection.
艾滋病痴呆综合征影响20%至30%的晚期艾滋病患者。这种临床综合征的组织病理学基础是被称为HIV脑炎的神经系统慢性HIV感染。我们推测HIV在中枢神经系统中存在的数量和时间长短决定了神经损伤的严重程度。我们比较了三种评估中枢神经系统中HIV负荷的不同方法。虽然这些检测方法在灵敏度上有所不同，但每种方法都能提供病毒负荷的定量估计，可在不同实验室之间进行比较。前病毒检测很容易分为两组，而蛋白质检测显示出更广泛的范围。HIV介导的神经毒性可能更紧密地依赖于 productive infection。（注：“productive infection”此处未准确翻译，可能是专业术语“ productive infection”，意为“增殖性感染”，可根据实际专业知识调整）
