Chen E Y
Department of Psychiatry, University of Hong Kong.
Can J Psychiatry. 1995 Feb;40(1):21-6. doi: 10.1177/070674379504000107.
This paper considers the relevance of hippocampal dysfunction to symptom production in schizophrenia with the help of an integrative computational model of cortical processing. First, evidence for involvement of the hippocampus was systematically reviewed. Then, a neural network model of hippocampal-cortical interaction was proposed. The effects of a dysfunction in hippocampal-cortical interaction were explored through simulation experiments. Neural network simulation demonstrated that when the hippocampal function of classification and reduction of overlap in input is sub-optimal, increasing correlation among input patterns compromised storage capacity of the cortical network. Hippocampal dysfunction predisposes to the emergence of spurious retrieval states in cortical information processing. This provides a model for psychotic symptom formation in schizophrenia.
本文借助皮层处理的综合计算模型，探讨海马功能障碍与精神分裂症症状产生之间的相关性。首先，系统回顾了海马参与其中的证据。然后，提出了一个海马-皮层相互作用的神经网络模型。通过模拟实验探究了海马-皮层相互作用功能障碍的影响。神经网络模拟表明，当海马对输入进行分类和减少重叠的功能次优时，输入模式之间相关性的增加会损害皮层网络的存储容量。海马功能障碍易导致皮层信息处理中出现虚假检索状态。这为精神分裂症的精神病性症状形成提供了一个模型。
